Medical schools struggle to meaningfully integrate basic science core concepts into the clinical curriculum, particularly in a manner that leverages understanding of causal mechanisms underlying common conditions to inform clinical reasoning. In this session, participants will collaboratively develop “integrated” illness scripts and consider applications of this cognitive integration method into their curricula. Illness scripts have been shown to be an effective method by which novices learn clinical reasoning skills. Cognitive research demonstrates that expert scientists and clinicians have difficulty “unpacking” their knowledge and making it available to teaching novice learners. Conversely, students often struggle to transfer basic science knowledge to clinical problem-solving. Development of ‘integrated’ illness scripts, whereby the key clinical findings of a given condition are clearly combined with the underlying basic science mechanism for each finding, is an effective means for integrating basic science concepts into students’ cognitive representations of core clinical conditions. Following a brief discussion regarding barriers to transfer and an evidence-based mini-didactic, participants will work in small teams to develop integrated illness scripts that demonstrate the basic science foundation for the clinical presentation of common pediatric conditions.